The Renal Drug Handbook, 3rd Edition

Product Information

Treatment given for fourteen to thirty days in other mucosal infections (oesophagitis, candiduria, non-invasive bronchopulmonary infections). Treatment of fungal infections of the skin and nails caused by Trichophyton (e.g. T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis or Epidermophyton floccosum dermatophytes.

Pharmaceutical Preformulation and Formulation: a Practical Guide from Candidate Drug Selection to Commercial Dosage Form - 2nd ed. (2009)Coccidioidomycosis: 200mg to 400mg daily. Treatment is for eleven months but can be increased to longer than twenty four months. 800mg daily may be necessary for some infections and in particular for meningeal disease.

Acute or recurrent vaginal candidiasis, candidal balanitis. Consider treatment of partners who present with symptomatic genital candidiasis. Spironolactone has not been shown to be anti-inflammatory, nor to affect the basic pathological process. Its use is only advised if glucocorticoids by themselves are insufficiently effective.

Treatment given for seven to fourteen days in oropharyngeal candidiasis (longer if required in severely immunocompromised patients).

The tablets should be taken in the morning before breakfast with water or a very small amount of food. Animal experiments indicate an increased incidence of congenital defects including the CNS system, palate and skeleton, when hydroxycarbamide is administered during pregnancy.Bennett WM, et al. Drug Prescribing in Renal Failure: Dosing guidelines for adults. 5 th ed. American College of Physicians; 2007. The manufacturers information should always be followed unless a renal specialist advises otherwise. Prescribing or administering a medication outside the manufacturers information may render the medicine being used off-label. Summary of Product Characteristics (SmPC) Quinine should be used only for the treatment of chloroquine-resistant malaria as the potential risk to the foetus due to treatment is much less than risks due to severe disease. Pregnant women treated with quinine are at risk of hypoglycaemia caused or exacerbated by quinine-induced hyperinsulinaemia. Renal function generally declines with age, and many elderly patients have a GFR less than 50 mL/min which, because of reduced muscle mass, may not be reflected by an elevated creatinine. Consequently, one can justifiably assume mild renal impairment when prescribing for the elderly.