Yves Saint Laurent Travel Selection Set: Black Opium Eau de Parfum 7.5ml, Libre Eau de Parfum 7.5ml, Libre Eau de Toilette 7.5ml & Mon Paris Eau de Parfum 7.5ml

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Abu Bakr Muhammad ibn Zakariya al-Razi (841–926)". Saudi Aramco World. January 2002 . Retrieved January 12, 2008. Ms Louise Foxcroft (June 28, 2013). The Making of Addiction: The 'Use and Abuse' of Opium in Nineteenth-Century Britain. Ashgate Publishing, Ltd. pp.66–. ISBN 978-1-4094-7984-0. Papaver somniferum, commonly known as the opium poppy [2] or breadseed poppy, [3] is a species of flowering plant in the family Papaveraceae. It is the species of plant from which both opium and poppy seeds are derived and is also a valuable ornamental plant grown in gardens. Its native range was east of the Mediterranean Sea, but now is obscured by ancient introductions and cultivation, being naturalized across much of Europe and Asia. Richard Askwith; The Sunday Times (September 13, 1998). "How aspirin turned hero" . Retrieved May 2, 2007. a b c d e f g Dikotter, Frank (2004). Narcotic Culture: A History of Drugs in China. Hurst. p.3. ISBN 978-0226149059.

Morewood, Samuel (1838). A philosophical and statistical history of the inventions and customs of ancient and modern nations in the manufacture and use of inebriating liquors; with the present practice of distillation in all its varieties: together with an extensive illustration of the consumption and effects of opium, and other stimulants used in the East, as substitutes for wine and spirits. Dublin, W. Curry and W. Carson. Opium prohibition in China began in 1729, yet was followed by nearly two centuries of increasing opium use. A massive destruction of opium by an emissary of the Chinese Daoguang Emperor in an attempt to stop opium smuggling by the British led to the First Opium War (1839–1842), in which Britain defeated China. After 1860, opium use continued to increase with widespread domestic production in China. By 1905, an estimated 25 percent of the male population were regular consumers of the drug. Recreational use of opium elsewhere in the world remained rare into late in the 19th century, as indicated by ambivalent reports of opium usage. [44] In 1906, 41,000 tons were produced, but because 39,000 tons of that year's opium were consumed in China, overall usage in the rest of the world was much lower. [48] These figures from 1906 have been criticized as overestimates. [49] A Chinese opium house; photographed in 1902 Dr Roland Quinault; Dr Ruth Clayton Windscheffel; Mr Roger Swift (July 28, 2013). William Gladstone: New Studies and Perspectives. Ashgate Publishing, Ltd. pp.238–. ISBN 978-1-4094-8327-4. Nye, Gideon (1873). The morning of my life in China: comprising an outline of the history of foreign intercourse from the last year of the regime of honorable East India Company, 1833, to the imprisonment of the foreign community in 1839.The production methods have not significantly changed since ancient times. Through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting Papaver orientale or Papaver bracteatum.

Both analgesia and drug addiction are functions of the mu opioid receptor, the class of opioid receptor first identified as responsive to morphine. Tolerance is associated with the superactivation of the receptor, which may be affected by the degree of endocytosis caused by the opioid administered, and leads to a superactivation of cyclic AMP signaling. [155] Long-term use of morphine in palliative care and the management of chronic pain always entails a risk that the patient develops tolerance or physical dependence. There are many kinds of rehabilitation treatment, including pharmacologically based treatments with naltrexone, methadone, or ibogaine. [156] Poppy seeds are a common and flavorsome topping for breads and cakes. One gram of poppy seeds contains up to 33 micrograms of morphine and 14 micrograms of codeine, and the Substance Abuse and Mental Health Services Administration in the United States formerly mandated that all drug screening laboratories use a standard cutoff of 300 nanograms per milliliter in urine samples. A single poppy seed roll (0.76grams of seeds) usually did not produce a positive drug test, but a positive result was observed from eating two rolls. A slice of poppy seed cake containing nearly five grams of seeds per slice produced positive results for 24 hours. Such results are viewed as false positive indications of drug use and were the basis of a legal defense. [117] [118] On November 30, 1998, the standard cutoff was increased to 2000 nanograms (two micrograms) per milliliter. [119] Confirmation by gas chromatography-mass spectrometry will distinguish amongst opium and variants including poppy seeds, heroin, and morphine and codeine pharmaceuticals by measuring the morphine:codeine ratio and looking for the presence of noscapine and acetylcodeine, the latter of which is only found in illicitly produced heroin, and heroin metabolites such as 6-monoacetylmorphine. [120] Harvesting and processing [ edit ] Harvesting opium a b P. G. Kritikos & S. P. Papadaki (January 1, 1967). "The early history of the poppy and opium". Journal of the Archaeological Society of Athens. Protocol for Limiting and Regulating the Cultivation of the Poppy Plant, the Production of, International and Wholesale Trade in, and Use of Opium

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a b c d e Brown Richard Harvey (2002). "The Opium Trade And Opium Policies In India, China, Britain, And The United States: Historical Comparisons And Theoretical Interpretations". Asian Journal of Social Science. 30 (3): 623. doi: 10.1163/156853102320945420. There is one accepted subspecies, P. somniferum subsp. setigerum (DC.) Arcang. [12] There are also many varieties and cultivars. Colors of the flowers vary widely, as do other physical characteristics, such as number and shape of petals [ citation needed], number of flowers and fruits, number of seeds, color of seeds, and production of opium. Papaver somniferum var. paeoniflorum is a variety with flowers that are highly double, and are grown in many colors. P. somniferum var. laciniatum is a variety with flowers that are highly double and deeply lobed. The variety Sujata produces no latex and no commercial utility for opioid production. Armero and Rapaport. The Arts of an Addiction. Qing Dynasty Opium Pipes and Accessories (privately printed, 2005) Production of thebaine and oripavine". April 20, 2004. Archived from the original on September 5, 2012 . Retrieved May 10, 2007.